Highly enantioselective Cu-catalysed allylic substitutions with Grignard reagents.
نویسندگان
چکیده
A catalyst system able to perform highly enantioselective Cu-catalysed allylic alkylations with Grignard reagents is described.
منابع مشابه
Cu-catalyzed asymmetric allylic alkylation of phosphonates and phosphine oxides with Grignard reagents.
An efficient and highly enantioselective copper-catalyzed allylic alkylation of phosphonates and phosphine oxides with Grignard reagents and Taniaphos or phosphoramidites as chiral ligands is reported. Transformation of these products leads to a variety of new phosphorus-containing chiral intermediates.
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To date, effective nickel-catalyzed enantioselective cross-couplings of alkyl electrophiles that bear oxygen leaving groups have been limited to reactions of allylic alcohol derivatives with Grignard reagents. In this Communication, we establish that, in the presence of a nickel/pybox catalyst, a variety of racemic propargylic carbonates are suitable partners for asymmetric couplings with organ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 4 شماره
صفحات -
تاریخ انتشار 2006